Accelerating
Drug Discovery Together
Structural Biology CRO & Crystallography
GIOS Biostructures is a structural biology CRO that offers a fully integrated service for structure determination, fragment based screening, de novo protein design and protein engineering. Using our automated X-ray crystallography platform, we can accelerate your research towards novel therapeutics, biomarkers and innovative drug discovery solutions.
Service packages
Gene to protein
Starting from a gene or protein sequence, we cover cloning, expression and purification, resulting in a highly pure protein product.
Protein to structure
We deliver high-quality X-ray data and structures through our automated X-ray crystallography platform and synchrotron access.
Fragment-based screening
We offer small-scale X-ray based fragment screening to assess protein druggability and discover druggable sites, including cryptic pockets.
AI-based protein design
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Complete pipeline of services
Our company offers a complete pipeline of services necessary to determine protein structures — from concept to final model. The process begins with a target protein or an idealized scaffold, which can be engineered using AI-driven methods and converted into a corresponding nucleotide sequence. This gene is then introduced into a suitable cellular system for protein expression. Our Protein-to-Structure workflow enables the production of milligram-scale quantities of protein, optimized for crystallization using our high-throughput platform. Finally, the resulting structures are delivered to the customer.
Latest posts
GIOS Biostructures has been awarded a VLAIO Innovation Startup Support (ISS) grant
This recognition means a great deal to us. VLAIO plays...
Read MoreEvolution of GPCR research
For decades, GPCRs were paradoxical targets: biologically central, yet structurally...
Read MoreIs X-ray crystallography nearing the end?
Is X-ray crystallography nearing the end of its era in...
Read More🚄 GIOS is heading to Dutch Life Sciences conference 2025
We look forward to connect with the vibrant Dutch biotech...
Read More